Well, of course it's an issue in terms of load times, but there's also nothing you can really do about it because that file simply contains all out of the box javascript Khoros could ever use on all of it's pages, it's an "oldschool" bundle that combines all various javascript libraries, plugins etc. into one file and over the years it grew to it's monstrous size... and "unused" bytes is also a bit tricky, they might be unused on the particular page you analyzed, but on otherpages other parts might be used...
